The DUROLANE Difference
Uniquely Formulated for Powerful and Long-lasting Pain Relief
DUROLANE is a non-animal, high-molecular weight, stabilized hyaluronic acid. It is stabilized using a carefully controlled cross-linking process that increases the intra-articular residence time 1,26,29.
The process of lightly cross-linking hyaluronic acid molecules in DUROLANE (0.5%-1%) changes the physical properties of the hyaluronic acid, forming a three-dimensional gel 1,30.
This unique technology allows for a half-life of 4 weeks or 32 days in the joint, following a single-injection 26,29.
DUROLANE has a longer half-life than unstabilized hyaluronic acid or cross-linked Synvisc® (hylan G-F 20) 31,32.
The most common side effects of DUROLANE in hip and knee studies were described as transient pain, stiffness and/or swelling localized to the joint. These adverse events were mild or moderate in intensity 33.
DUROLANE is safe for repeated courses of therapy. Studies investigating repeated treatment 6 months following the initial injection did not cause an increased rate of adverse events 33.